Here I will try to list all supplements and treatments I have tried as well as the motivation behind them. So far my decline has been very constant at about one ALSFRS-R point a month, so none of the things have had a significant effect in slowing down the disease. ADDENDUM: Between January and May 2014 I have only lost 1 or 2 points, so the decline has clearly slowed down around December. It is impossible to say, however, if it is just random fluctuation or possibly an effect of some of the things I changed around that time.
Methylcobalamin (vitamin B12): August 2012 - December 2012 sublingually about 10 mg/day. Justification: http://www.ncbi.nlm.nih.gov/pubmed/8021696
Lyme disease treatment: Will be described in a separate article.
Vitamin C: August 2012 - November 2012 orally, gradually increasing to 7 g a day. Justification: antioxidative effects, potential role in countering Lyme disease.
Low dose Naltrexone: Jan 2013 - Mar 2013. Justification: anecdotal.
Human breast milk: Feb 2013 - Apr 2013. Justification: happened to have a surplus supply, plus it is found to contain a fair amount of pluripotent stem cells (however, no idea if any of them actually can pass to the bloodstream or BBB).
Deanna Protocol: April 2013 - June 2013 (at which point I dropped the coconut oil, AKG and AAKG megadosing - otherwise I still keep taking the supplements of the protocol). Justification: anecdotal reports on slowed-down disease progression. See http://www.winningthefight.net for up-to-date information regarding the protocol.
Nitrous oxide (laughing gas): June 2013 - August 2013. 128 g/day inhaled within 20-30 minutes. Justification: speculation of possible immunosuppressive effect on the neuroinflammation; easier access than to proper anesthetics.
Oral Sodium Chlorite (OSC): Original formula (July 2013), concentrated formula (October 2013); see the relevant discussion threads on als.net for more accurate descriptions. Justification: positive experience reported by some participants of the Neuraltus NP001 trial.
Valerian root: Jun 2013 - Aug 2013 and again since March 2014. Justification: neuroprotective effects. http://www.ncbi.nlm.nih.gov/pubmed/15325965
Propofol: First test on Dec 20, 2013. See separate report. Justification: anecdotal reports on temporarily relief plus a hypothesis on immunosuppressive action on neuroinflammation. Temporary improvement observed in UMN symptoms concerning swallowing and leg control.
Dextromethorphan: Started Jan 2014. 30 mg three times a day. Justification: anecdotal reports concerning effect on UMN/bulbar symptoms and possibly disease progression rate. Lowered the dose to 30 mg twice a day within the first two months.
NADH: Started Feb 2014. 60-80 mg per day sublingually (20 mg per dose). Justification: see Deanna Protocol.
Distillation of all drinking water: Started Feb 2014. Justification: we have well water with excessive iron in it and no way to be absolutely certain of all other pollutants (such as BMAA). Electrolytes added in the form as rose salt after distillation.
Dichloroacetate: Started May 2014. 500 mg/l added to drinking water. Justification: turns astrocyte metabolism from glycolysis towards phosphorylation.
My current daily "pile of pills" - will be sorted out later.
Currently I'm taking the following set twice a day
Niacin 250mg 1 Nutricology
Vitamin B-complex 100 100mg B1,B2,B3,B5,B6, B12, folate, biotine etc. Solgar
5-HTP 100mg 3 ProThera
Gaba 250mg 2 Kirkman
Alpha-Lipoic Acid 150mg 2 Klaire Labs
Chinese Skullcap 400mg 2 Swanson
Turmeric root extract 400mg 2 Solgar
Vitamin C 500mg 1
Magnesium oxcide 350mg 1
L-Carnosin 400mg 1
Gingonis extr. 63mg 1
Uniquinol 600mg 2
In addition, the following substances during the day, mixed in water:
AAKG, taurine, liposomal glutathione and creatine pyruvate 4 teaspoons each.